Protein Details: Neuronal acetylcholine receptor subunit alpha-4
Protein ID
ICDB_Pro_0319
Protein Name
Neuronal acetylcholine receptor subunit alpha-4
Gene Name
Chrna4; Acra4
Organism
Rattus norvegicus (Rat)
Length
630 amino acids
AlphaFoldDB
AF-P09483-F1-model_v4.pdb
Function
After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Sequence
MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSPTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAVETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQEAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKEPSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAAC
PDB Structures
Ligand Binding
Binding Site
Disease
Location
In various regions of the central nervous system
DOI ID
10.1016/0092-8674(87)90705-7; 10.1016/0014-5793(87)80272-7; 10.1074/jbc.m504229200; 10.1074/jbc.m111.328294; 10.1096/fj.12-204487; 10.1038/ncomms1871
RefSeq
NP_077330.1